BPC-157 (Body Protection Compound-157) is a stable 15-amino-acid pentadecapeptide derived from a partial sequence of a human gastric-juice protein. It is studied as a cytoprotective and pro-angiogenic regulator acting through VEGFR2 and FAK–paxillin signaling. This product is supplied as a lyophilized research-grade peptide for in vitro and preclinical laboratory investigation only.
| Names | BPC-157 · Body Protection Compound-157 |
| Sequence | GEPPPGKPADDAGLV (15 aa) |
| Length | 15 amino acids (pentadecapeptide) |
| Molecular formula | C62H98N16O22 |
| Molecular weight | 1419.5 Da |
| Origin | Partial sequence of human gastric-juice protein BPC |
| Safety | No lethal dose (LD1) reached in animal studies |
| Development | Sikiric group (Zagreb) · clinical candidate PL-14736 |
Investigational directions enabled by the published mechanism — not therapeutic claims.
- ◆Tissue repair & regeneration: fibroblast activity and collagen production in tendon, muscle and ligament models
- ◆Angiogenesis: new blood-vessel formation via VEGFR2 signaling
- ◆Neurological research: nerve regeneration and functional recovery in injury models
- ◆Gastrointestinal cytoprotection: gastric-ulcer and inflammatory-bowel-type experimental models
In published models, BPC-157 drives angiogenesis and endothelial repair through the VEGFR2–PI3K–Akt–eNOS axis, while FAK–paxillin activation supports cell migration and tendon/ligament outgrowth. It upregulates the growth-hormone receptor on tendon fibroblasts and modulates the NO system (eNOS↑ / iNOS↓) toward cytoprotection and radical scavenging.
Key literature: Chang et al., 2011, J Appl Physiol · Staresinic et al., 2003 · Seiwerth et al., 2021 · Perovic et al., 2019.
Evidence note: approximately 80% of the BPC-157 literature originates from a single research group (Sikiric, Zagreb); independent replication remains limited.
| Intended use | Research use only — not an approved drug |
| FDA | Category 2 (not approved; compounding-restricted) |
| WADA | Prohibited (S0 — non-approved substances) |
| Human data | Phase-2 IBD (PL-14736) & MS trials; no large RCT |
- ◆Packaging: 5 × 5 mg lyophilized powder, sterile glass vials
- ◆Storage: Store at 2–8 °C (refrigerated)
- ◆Solubility: Dissolves readily in bacteriostatic water
- ◆Reconstitution: Use shortly after preparation for stability
- ◆Purity: HPLC-verified ≥ 98% · batch CoA
|
◆ Purity HPLC-verified ≥ 98% with batch CoA |
◆ Evidence Peer-reviewed citations for all mechanistic claims |
◆ Transparency Evidence limitations stated per molecule |
◆ Safety Research use only — not for human or animal consumption |
TFLL Pharma · TFLL BV · Belgium · Life Span · Health Span · Brain Span · www.tfllpharma.com
Related product