{"product_id":"semax-10-mg-spray","title":"Semax (10 mg) 195€ + Shipping","description":"\u003cdiv class=\"tfll-pdp\" style=\"max-width: 840px; margin: 0 auto; font-family: Calibri,'Segoe UI',Arial,sans-serif; color: #0d1b3e; line-height: 1.55;\"\u003e\n\u003c!-- TOP ACCENT BAR --\u003e\n\u003cdiv style=\"height: 5px; background: #E8722A; margin-bottom: 0;\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c!-- 1 · SECTION TAG + TITLE --\u003e\n\u003cdiv style=\"background: #F7F5F1; padding: 18px 20px;\"\u003e\n\u003cdiv style=\"display: inline-block; background: #2563B0; color: #ffffff; font-size: 11px; letter-spacing: 2px; font-weight: bold; padding: 4px 12px; text-transform: uppercase;\"\u003eTFLL Pharma · Molecule 10 · Neuro-peptide\u003c\/div\u003e\n\u003cdiv style=\"font-family: 'Palatino Linotype',Palatino,Georgia,serif; font-size: 34px; color: #0d1b3e; margin-top: 12px; line-height: 1.1;\"\u003eSemax\u003c\/div\u003e\n\u003cdiv style=\"font-family: 'Palatino Linotype',Palatino,Georgia,serif; font-style: italic; font-size: 15px; color: #5a6473; margin-top: 4px;\"\u003eACTH(4–7)-Pro-Gly-Pro — Neurotrophic Regulatory Heptapeptide · Nasal Spray 1 mg\/mL\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c!-- 2 · INTRO --\u003e\n\u003cp style=\"margin: 18px 0;\"\u003eSemax is a synthetic neurotrophic heptapeptide built from the ACTH(4–7) core plus a C-terminal Pro-Gly-Pro (PGP) extension that improves proteolytic stability. It lacks the corticotropic (adrenal) activity of ACTH and is studied primarily for BDNF\/TrkB-mediated neurotrophic signaling and ischemic-injury transcriptomics. This product is supplied as a research-grade aqueous nasal-spray solution for in vitro, ex vivo and analytical research only.\u003c\/p\u003e\n\u003c!-- 3 · IDENTITY --\u003e\n\u003cdiv style=\"font-family: 'Palatino Linotype',Palatino,Georgia,serif; font-size: 20px; color: #0d1b3e; border-bottom: 2px solid #4338CA; padding-bottom: 6px; margin: 24px 0 12px;\"\u003eIdentity\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; margin-bottom: 20px; font-size: 14px;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA; color: #2563b0; font-weight: bold; width: 34%; vertical-align: top;\"\u003eSequence\u003c\/td\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA;\"\u003eMet-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA; color: #2563b0; font-weight: bold; vertical-align: top;\"\u003eDesign\u003c\/td\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA;\"\u003eACTH(4–7) core + C-terminal Pro-Gly-Pro (PGP) extension\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA; color: #2563b0; font-weight: bold; vertical-align: top;\"\u003eLength\u003c\/td\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA;\"\u003e7 amino acids (heptapeptide)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA; color: #2563b0; font-weight: bold; vertical-align: top;\"\u003eMolecular formula\u003c\/td\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA;\"\u003eC\u003csub\u003e37\u003c\/sub\u003eH\u003csub\u003e51\u003c\/sub\u003eN\u003csub\u003e9\u003c\/sub\u003eO\u003csub\u003e10\u003c\/sub\u003eS\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA; color: #2563b0; font-weight: bold; vertical-align: top;\"\u003eMolecular weight\u003c\/td\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA;\"\u003e813.9 Da\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA; color: #2563b0; font-weight: bold; vertical-align: top;\"\u003eCAS\u003c\/td\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA;\"\u003e80714-61-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA; color: #2563b0; font-weight: bold; vertical-align: top;\"\u003eClass\u003c\/td\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA;\"\u003eMelanocortin-derived regulatory peptide; lacks ACTH corticotropic activity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA; color: #2563b0; font-weight: bold; vertical-align: top;\"\u003eOrigin\u003c\/td\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA;\"\u003eInstitute of Molecular Genetics, Russian Academy of Sciences (Ashmarin, Myasoedov)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c!-- 4 · RESEARCH AXES --\u003e\n\u003cdiv style=\"font-family: 'Palatino Linotype',Palatino,Georgia,serif; font-size: 20px; color: #0d1b3e; border-bottom: 2px solid #4338CA; padding-bottom: 6px; margin: 24px 0 12px;\"\u003eResearch axes\u003c\/div\u003e\n\u003cp style=\"margin: 0 0 8px; font-size: 13px; color: #5a6473; font-style: italic;\"\u003eInvestigational directions enabled by the published mechanism — not therapeutic claims.\u003c\/p\u003e\n\u003cul style=\"margin: 0 0 20px; padding-left: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 6px 0 6px 22px; border-bottom: 1px solid #F0EEE9; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #e8722a; font-weight: bold;\"\u003e◆\u003c\/span\u003eNeurotrophic signaling: BDNF exon III transcription and TrkB phosphorylation in rat hippocampus\u003c\/li\u003e\n\u003cli style=\"padding: 6px 0 6px 22px; border-bottom: 1px solid #F0EEE9; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #e8722a; font-weight: bold;\"\u003e◆\u003c\/span\u003eIschemic-injury research: post-ischemic transcriptome (394 DEGs, tMCAO 24 h)\u003c\/li\u003e\n\u003cli style=\"padding: 6px 0 6px 22px; border-bottom: 1px solid #F0EEE9; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #e8722a; font-weight: bold;\"\u003e◆\u003c\/span\u003eMonoaminergic modulation: dopaminergic\/serotonergic activation in rodent striatum\u003c\/li\u003e\n\u003cli style=\"padding: 6px 0 6px 22px; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #e8722a; font-weight: bold;\"\u003e◆\u003c\/span\u003eNeuroimmune transcriptomics: immune-response and vasculogenesis gene programs post-ischemia\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- 5 · MECHANISM --\u003e\n\u003cdiv style=\"font-family: 'Palatino Linotype',Palatino,Georgia,serif; font-size: 20px; color: #0d1b3e; border-bottom: 2px solid #4338CA; padding-bottom: 6px; margin: 24px 0 12px;\"\u003eMechanism at a glance\u003c\/div\u003e\n\u003cp style=\"margin: 0 0 8px;\"\u003eIn published models, Semax upregulates BDNF exon III transcription and increases TrkB tyrosine phosphorylation in rat hippocampus, with rapid BDNF\/NGF mRNA induction in basal-forebrain glial cultures. In ischemia models the transcriptome shifts — inflammatory genes down, neurotransmission genes up — and dopaminergic\/serotonergic systems are activated in the rodent striatum.\u003c\/p\u003e\n\u003cp style=\"margin: 0 0 8px; font-size: 13px; color: #5a6473;\"\u003eKey literature: Dolotov et al., 2006, \u003cem\u003eJ Neurochem\u003c\/em\u003e · Shadrina et al., 2001 · Filippenkov et al., 2020 · Medvedeva et al., 2014 \/ 2017.\u003c\/p\u003e\n\u003cp style=\"margin: 0 0 20px; font-size: 13px; color: #5a6473;\"\u003e\u003cspan style=\"color: #4338ca; font-weight: bold;\"\u003eEvidence note:\u003c\/span\u003e neurotrophin induction is the best-characterized axis; the primary receptor remains unidentified. Early screening reported MC4R antagonism (Adan 1994), but whether melanocortin receptors mediate the neurotrophic effects is unresolved.\u003c\/p\u003e\n\u003c!-- 6 · REGULATORY STATUS --\u003e\n\u003cdiv style=\"font-family: 'Palatino Linotype',Palatino,Georgia,serif; font-size: 20px; color: #0d1b3e; border-bottom: 2px solid #4338CA; padding-bottom: 6px; margin: 24px 0 12px;\"\u003eRegulatory status\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; margin-bottom: 20px; font-size: 14px;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA; color: #2563b0; font-weight: bold; width: 34%; vertical-align: top;\"\u003eIntended use\u003c\/td\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA;\"\u003eIn vitro, ex vivo and analytical research only — not for human or animal use\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA; color: #2563b0; font-weight: bold; vertical-align: top;\"\u003eRegistration\u003c\/td\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA;\"\u003eRegistered as a drug in Russia only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA; color: #2563b0; font-weight: bold; vertical-align: top;\"\u003eFDA \/ EMA \/ TİTCK\u003c\/td\u003e\n\u003ctd style=\"padding: 8px 10px; border-bottom: 1px solid #E4E1DA;\"\u003eNot approved\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c!-- 7 · PRODUCT FORMAT \u0026 HANDLING (dark panel) --\u003e\n\u003cdiv style=\"background: #0D1B3E; border-radius: 10px; padding: 20px 22px; margin: 24px 0;\"\u003e\n\u003cdiv style=\"font-family: 'Palatino Linotype',Palatino,Georgia,serif; font-size: 19px; color: #ffffff; margin-bottom: 12px;\"\u003eProduct format \u0026amp; handling\u003c\/div\u003e\n\u003cul style=\"margin: 0; padding-left: 0; list-style: none; color: #a8b0bc; font-size: 14px;\"\u003e\n\u003cli style=\"padding: 6px 0 6px 22px; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #e8722a; font-weight: bold;\"\u003e◆\u003c\/span\u003e\u003cspan style=\"color: #ffffff; font-weight: bold;\"\u003eFormat:\u003c\/span\u003e Metered nasal-spray pump · aqueous solution\u003c\/li\u003e\n\u003cli style=\"padding: 6px 0 6px 22px; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #e8722a; font-weight: bold;\"\u003e◆\u003c\/span\u003e\u003cspan style=\"color: #ffffff; font-weight: bold;\"\u003eConcentration:\u003c\/span\u003e 1 mg\/mL · 10 mL bottle (10 mg total content)\u003c\/li\u003e\n\u003cli style=\"padding: 6px 0 6px 22px; position: relative;\"\u003e\u003cspan style=\"position: absolute; left: 0; color: #e8722a; font-weight: bold;\"\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"padding: 6px 0 6px 22px; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #e8722a; font-weight: bold;\"\u003e◆\u003c\/span\u003e\u003cspan style=\"color: #ffffff; font-weight: bold;\"\u003eSterility:\u003c\/span\u003e Non-sterile — not for parenteral preparation\u003c\/li\u003e\n\u003cli style=\"padding: 6px 0 6px 22px; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #e8722a; font-weight: bold;\"\u003e◆\u003c\/span\u003e\u003cspan style=\"color: #ffffff; font-weight: bold;\"\u003eStorage:\u003c\/span\u003e 2–8 °C, protect from light (Met¹ is oxidation-sensitive)\u003c\/li\u003e\n\u003cli style=\"padding: 6px 0 6px 22px; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #e8722a; font-weight: bold;\"\u003e◆\u003c\/span\u003e\u003cspan style=\"color: #ffffff; font-weight: bold;\"\u003eIdentity:\u003c\/span\u003e Batch CoA — HPLC purity (≥ 98%) + MS mass confirmation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c!-- 8 · RESEARCH QUALITY BAND --\u003e\n\u003cdiv style=\"background: #0D1B3E; border-left: 6px solid #E8722A; padding: 20px 22px; margin: 24px 0;\"\u003e\n\u003cdiv style=\"font-family: 'Palatino Linotype',Palatino,Georgia,serif; font-size: 20px; color: #ffffff;\"\u003eResearch Quality \u0026amp; Scientific Integrity\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; margin-top: 12px; font-size: 13px; color: #a8b0bc;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 6px 12px 6px 0; vertical-align: top; width: 25%;\"\u003e\n\u003cspan style=\"color: #e8722a;\"\u003e◆\u003c\/span\u003e \u003cspan style=\"color: #ffffff; font-weight: bold;\"\u003ePurity\u003c\/span\u003e\u003cbr\u003eHPLC ≥ 98% + MS mass confirmation (batch CoA)\u003c\/td\u003e\n\u003ctd style=\"padding: 6px 12px; vertical-align: top; width: 25%;\"\u003e\n\u003cspan style=\"color: #e8722a;\"\u003e◆\u003c\/span\u003e \u003cspan style=\"color: #ffffff; font-weight: bold;\"\u003eEvidence\u003c\/span\u003e\u003cbr\u003ePeer-reviewed citations for all mechanistic claims\u003c\/td\u003e\n\u003ctd style=\"padding: 6px 12px; vertical-align: top; width: 25%;\"\u003e\n\u003cspan style=\"color: #e8722a;\"\u003e◆\u003c\/span\u003e \u003cspan style=\"color: #ffffff; font-weight: bold;\"\u003eTransparency\u003c\/span\u003e\u003cbr\u003eEvidence limitations stated per molecule\u003c\/td\u003e\n\u003ctd style=\"padding: 6px 0 6px 12px; vertical-align: top; width: 25%;\"\u003e\n\u003cspan style=\"color: #e8722a;\"\u003e◆\u003c\/span\u003e \u003cspan style=\"color: #ffffff; font-weight: bold;\"\u003eSafety\u003c\/span\u003e\u003cbr\u003eResearch use only — not for human or animal consumption\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c!-- 9 · RUO DISCLAIMER --\u003e\n\u003cdiv style=\"background: #0D1B3E; color: #a8b0bc; padding: 16px 18px; font-size: 12.5px; line-height: 1.6;\"\u003e\n\u003cspan style=\"color: #e8722a; font-weight: bold;\"\u003eFor Research Use Only.\u003c\/span\u003e This product is strictly intended for laboratory and research use only. Not suitable for human or animal consumption, diagnostic, or therapeutic use. All use must comply with local regulations and ethical research standards.\u003cbr\u003e\u003cspan style=\"color: #ffffff;\"\u003eTFLL Pharma · TFLL BV · Belgium\u003c\/span\u003e · Life Span · Health Span · Brain Span · www.tfllpharma.com\u003c\/div\u003e\n\u003c\/div\u003e","brand":"customsupplements","offers":[{"title":"Default Title","offer_id":59324761866588,"sku":null,"price":195.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0617\/0014\/5391\/files\/semax_spray.jpg?v=1793712009","url":"https:\/\/customsupplementsshop.com\/fr\/products\/semax-10-mg-spray","provider":"customsupplements","version":"1.0","type":"link"}