NAD+ (125 mg) 5 vials ^Sale

Nicotinamide adenine dinucleotide (NAD⁺) is a critical coenzyme found in every living cell, necessary for energy metabolism, mitochondrial function, DNA repair, and cell signaling. In its oxidized form it participates in redox reactions by accepting electrons, making it vital for cellular respiration and ATP production. Intracellular NAD⁺ declines substantially with age, driving intense research interest in NAD⁺-boosting strategies. This product is supplied as a lyophilized research-grade powder for intravenous research preparations, for in vitro and preclinical laboratory investigation only.

Investigational directions enabled by the published mechanism — not therapeutic claims.

• ◆Energy production & mitochondrial health: electron transport, ATP synthesis, SIRT3 / PGC-1α / TFAM biogenesis
• ◆Longevity & sirtuin activation: SIRT1–7 deacetylase regulation of aging, inflammation and repair
• ◆DNA repair & genome stability: PARP1 substrate supply; genome-integrity and cancer-biology models
• ◆Neuroprotective research: NAD⁺/autophagy–SIRT1 axis, Aβ clearance and Parkin-mediated mitophagy

In published models, NAD⁺ drives SIRT1–7 deacetylase activity, linking it to epigenetic regulation, metabolic gene expression, DNA repair, and mitochondrial biogenesis. PARP1 consumes NAD⁺ for DNA strand-break repair, so chronic damage can hyperactivate PARP1, deplete NAD⁺ and suppress sirtuins. The CD38 ectoenzyme is a primary driver of age-related NAD⁺ decline, rising in aging immune cells, while NAMPT-dependent salvage is rate-limiting and falls with age.

Key literature: Covarrubias et al., 2021, Nat Rev Mol Cell Biol · Lautrup et al., 2019, Cell Metab · Zhang et al., 2016, Science · Fang et al., 2014, Cell.