{"product_id":"selank-10-mg-spray","title":"Selank (10 mg) 195€ + Shipping","description":"\u003c!--\n  TFLL PHARMA — Shopify product-body HTML (EN source)\n  Molecule 11 · Selank · NASAL SPRAY (1 mg\/mL solution, 10 mL) · structural accent #BE185D\n  Aligned to TFLL_Pharma Selank deck + product spec: 1 mg\/mL, 10 mL bottle, ~250 mcg\/actuation.\n  PASTE: copy from \u003cdiv class=\"tfll-pdp\"...\u003e to the final \u003c\/div\u003e\n         into the product description via Shopify's \u003c\u003e (Show HTML) editor.\n  T Lab \/ Translate \u0026 Adapt keeps this structure; you only review\/approve NL + FR text.\n--\u003e\n\u003cdiv class=\"tfll-pdp\" style=\"max-width:840px;margin:0 auto;font-family:Calibri,'Segoe UI',Arial,sans-serif;color:#0D1B3E;line-height:1.55;\"\u003e\n\n  \u003c!-- TOP ACCENT BAR --\u003e\n  \u003cdiv style=\"height:5px;background:#E8722A;margin-bottom:0;\"\u003e\u003c\/div\u003e\n\n  \u003c!-- 1 · SECTION TAG + TITLE --\u003e\n  \u003cdiv style=\"background:#F7F5F1;padding:18px 20px;\"\u003e\n    \u003cdiv style=\"display:inline-block;background:#2563B0;color:#FFFFFF;font-size:11px;letter-spacing:2px;font-weight:bold;padding:4px 12px;text-transform:uppercase;\"\u003eTFLL Pharma · Molecule 11 · Neuro-peptide\u003c\/div\u003e\n    \u003cdiv style=\"font-family:'Palatino Linotype',Palatino,Georgia,serif;font-size:34px;color:#0D1B3E;margin-top:12px;line-height:1.1;\"\u003eSelank\u003c\/div\u003e\n    \u003cdiv style=\"font-family:'Palatino Linotype',Palatino,Georgia,serif;font-style:italic;font-size:15px;color:#5A6473;margin-top:4px;\"\u003eTuftsin-Derived Heptapeptide — Enkephalinergic \/ GABAergic \/ Neuroimmune Axis · Nasal Spray 1 mg\/mL\u003c\/div\u003e\n  \u003c\/div\u003e\n\n  \u003c!-- 2 · INTRO --\u003e\n  \u003cp style=\"margin:18px 0;\"\u003eSelank is a synthetic analog of tuftsin — the immunoactive IgG heavy-chain fragment — with a C-terminal Pro-Gly-Pro (PGP) tail added for peptidase resistance. It shares the glyproline stabilizing strategy of its sister molecule Semax. Selank is studied as a multi-target regulatory peptide across enkephalinergic, GABAergic and neuroimmune axes. This product is supplied as a research-grade aqueous nasal-spray solution for in vitro, ex vivo and analytical research only.\u003c\/p\u003e\n\n  \u003c!-- 3 · IDENTITY --\u003e\n  \u003cdiv style=\"font-family:'Palatino Linotype',Palatino,Georgia,serif;font-size:20px;color:#0D1B3E;border-bottom:2px solid #BE185D;padding-bottom:6px;margin:24px 0 12px;\"\u003eIdentity\u003c\/div\u003e\n  \u003ctable style=\"width:100%;border-collapse:collapse;margin-bottom:20px;font-size:14px;\"\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;width:34%;vertical-align:top;\"\u003eSequence\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eThr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP, 7 aa)\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eDesign\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eTuftsin (TKPR, IgG-derived) + C-terminal Pro-Gly-Pro\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eLength\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003e7 amino acids, linear, unmodified termini\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eParent\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eTuftsin — immunoactive IgG heavy-chain fragment\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eMolecular formula\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eC\u003csub\u003e33\u003c\/sub\u003eH\u003csub\u003e57\u003c\/sub\u003eN\u003csub\u003e11\u003c\/sub\u003eO\u003csub\u003e9\u003c\/sub\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eMolecular weight\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003e≈ 752 Da\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eClass\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eGlyproline regulatory peptide · anxiolytic \/ immunomodulatory\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eSister molecule\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eSemax (ACTH4–7 + PGP) — same glyproline strategy\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eOrigin\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eInstitute of Molecular Genetics (RAS) · Zakusov Institute\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n\n  \u003c!-- 4 · RESEARCH AXES --\u003e\n  \u003cdiv style=\"font-family:'Palatino Linotype',Palatino,Georgia,serif;font-size:20px;color:#0D1B3E;border-bottom:2px solid #BE185D;padding-bottom:6px;margin:24px 0 12px;\"\u003eResearch axes\u003c\/div\u003e\n  \u003cp style=\"margin:0 0 8px;font-size:13px;color:#5A6473;font-style:italic;\"\u003eInvestigational directions enabled by the published mechanism — not therapeutic claims.\u003c\/p\u003e\n  \u003cul style=\"margin:0 0 20px;padding-left:0;list-style:none;\"\u003e\n    \u003cli style=\"padding:6px 0 6px 22px;border-bottom:1px solid #F0EEE9;position:relative;\"\u003e\n\u003cspan style=\"position:absolute;left:0;color:#E8722A;font-weight:bold;\"\u003e◆\u003c\/span\u003eAnxiety \u0026amp; stress neurobiology: behavioral anxiety models (EPM, chronic mild stress) and benzodiazepine-interaction studies\u003c\/li\u003e\n    \u003cli style=\"padding:6px 0 6px 22px;border-bottom:1px solid #F0EEE9;position:relative;\"\u003e\n\u003cspan style=\"position:absolute;left:0;color:#E8722A;font-weight:bold;\"\u003e◆\u003c\/span\u003eOpioid-peptide homeostasis: enkephalin degradation kinetics and peptidase inhibition\u003c\/li\u003e\n    \u003cli style=\"padding:6px 0 6px 22px;border-bottom:1px solid #F0EEE9;position:relative;\"\u003e\n\u003cspan style=\"position:absolute;left:0;color:#E8722A;font-weight:bold;\"\u003e◆\u003c\/span\u003eNeurotrophic signaling: hippocampal BDNF regulation after intranasal delivery (plasticity, memory)\u003c\/li\u003e\n    \u003cli style=\"padding:6px 0 6px 22px;position:relative;\"\u003e\n\u003cspan style=\"position:absolute;left:0;color:#E8722A;font-weight:bold;\"\u003e◆\u003c\/span\u003eNeuroimmune crosstalk: cytokine modulation (IL-6, Th1\/Th2) inherited from the tuftsin scaffold\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003c!-- 5 · MECHANISM --\u003e\n  \u003cdiv style=\"font-family:'Palatino Linotype',Palatino,Georgia,serif;font-size:20px;color:#0D1B3E;border-bottom:2px solid #BE185D;padding-bottom:6px;margin:24px 0 12px;\"\u003eMechanism at a glance\u003c\/div\u003e\n  \u003cp style=\"margin:0 0 8px;\"\u003eIn published models, Selank inhibits enkephalinase (IC50 ≈ 15 µM), prolonging Leu-enkephalin half-life, and shows a transcriptional profile overlapping GABAergic signaling. Intranasal dosing raises hippocampal BDNF expression in rats, and the tuftsin-derived immune arm modulates IL-6 and Th1\/Th2 cytokine balance.\u003c\/p\u003e\n  \u003cp style=\"margin:0 0 8px;font-size:13px;color:#5A6473;\"\u003eKey literature: Zozulya et al., 2001 · Inozemtseva et al., 2008 · Uchakina et al., 2008 · Kasian et al., 2017.\u003c\/p\u003e\n  \u003cp style=\"margin:0 0 20px;font-size:13px;color:#5A6473;\"\u003e\u003cspan style=\"color:#BE185D;font-weight:bold;\"\u003eEvidence note:\u003c\/span\u003e the mechanism is multi-target — no single receptor has been defined; GABAergic effects are transcriptional and not seen in all cell models (e.g. IMR-32, 2017).\u003c\/p\u003e\n\n  \u003c!-- 6 · REGULATORY STATUS --\u003e\n  \u003cdiv style=\"font-family:'Palatino Linotype',Palatino,Georgia,serif;font-size:20px;color:#0D1B3E;border-bottom:2px solid #BE185D;padding-bottom:6px;margin:24px 0 12px;\"\u003eRegulatory status\u003c\/div\u003e\n  \u003ctable style=\"width:100%;border-collapse:collapse;margin-bottom:20px;font-size:14px;\"\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;width:34%;vertical-align:top;\"\u003eIntended use\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eResearch use only — not an approved drug; not for human or animal use\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eRegistration\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eRegistered in Russia (anxiety \/ neurasthenia, intranasal)\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eFDA \/ EMA \/ TİTCK\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eNot approved · TİTCK: no registration\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eWADA\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eNot listed by name; S0 applicability to be confirmed\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;color:#2563B0;font-weight:bold;vertical-align:top;\"\u003eGuidance\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #E4E1DA;\"\u003eNo dosing or administration guidance is provided\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n\n  \u003c!-- 7 · PRODUCT FORMAT \u0026 HANDLING (dark panel) --\u003e\n  \u003cdiv style=\"background:#0D1B3E;border-radius:10px;padding:20px 22px;margin:24px 0;\"\u003e\n    \u003cdiv style=\"font-family:'Palatino Linotype',Palatino,Georgia,serif;font-size:19px;color:#FFFFFF;margin-bottom:12px;\"\u003eProduct format \u0026amp; handling\u003c\/div\u003e\n    \u003cul style=\"margin:0;padding-left:0;list-style:none;color:#A8B0BC;font-size:14px;\"\u003e\n      \u003cli style=\"padding:6px 0 6px 22px;position:relative;\"\u003e\n\u003cspan style=\"position:absolute;left:0;color:#E8722A;font-weight:bold;\"\u003e◆\u003c\/span\u003e\u003cspan style=\"color:#FFFFFF;font-weight:bold;\"\u003eFormat:\u003c\/span\u003e Metered nasal-spray pump · aqueous solution\u003c\/li\u003e\n      \u003cli style=\"padding:6px 0 6px 22px;position:relative;\"\u003e\n\u003cspan style=\"position:absolute;left:0;color:#E8722A;font-weight:bold;\"\u003e◆\u003c\/span\u003e\u003cspan style=\"color:#FFFFFF;font-weight:bold;\"\u003eConcentration:\u003c\/span\u003e 1 mg\/mL · 10 mL bottle (10 mg total content)\u003c\/li\u003e\n      \u003cli style=\"padding:6px 0 6px 22px;position:relative;\"\u003e\n\u003cspan style=\"position:absolute;left:0;color:#E8722A;font-weight:bold;\"\u003e◆\u003c\/span\u003e\u003cspan style=\"color:#FFFFFF;font-weight:bold;\"\u003eMetered delivery:\u003c\/span\u003e ~250 mcg per actuation (~40 actuations per bottle)\u003c\/li\u003e\n      \u003cli style=\"padding:6px 0 6px 22px;position:relative;\"\u003e\n\u003cspan style=\"position:absolute;left:0;color:#E8722A;font-weight:bold;\"\u003e◆\u003c\/span\u003e\u003cspan style=\"color:#FFFFFF;font-weight:bold;\"\u003eGrade:\u003c\/span\u003e Research use only (RUO) — not for human use\u003c\/li\u003e\n      \u003cli style=\"padding:6px 0 6px 22px;position:relative;\"\u003e\n\u003cspan style=\"position:absolute;left:0;color:#E8722A;font-weight:bold;\"\u003e◆\u003c\/span\u003e\u003cspan style=\"color:#FFFFFF;font-weight:bold;\"\u003eStorage:\u003c\/span\u003e 2–8 °C, protect from light\u003c\/li\u003e\n      \u003cli style=\"padding:6px 0 6px 22px;position:relative;\"\u003e\n\u003cspan style=\"position:absolute;left:0;color:#E8722A;font-weight:bold;\"\u003e◆\u003c\/span\u003e\u003cspan style=\"color:#FFFFFF;font-weight:bold;\"\u003eIdentity:\u003c\/span\u003e Batch CoA — HPLC purity (≥ 98%) + concentration as stated\u003c\/li\u003e\n    \u003c\/ul\u003e\n  \u003c\/div\u003e\n\n  \u003c!-- 8 · RESEARCH QUALITY BAND --\u003e\n  \u003cdiv style=\"background:#0D1B3E;border-left:6px solid #E8722A;padding:20px 22px;margin:24px 0;\"\u003e\n    \u003cdiv style=\"font-family:'Palatino Linotype',Palatino,Georgia,serif;font-size:20px;color:#FFFFFF;\"\u003eResearch Quality \u0026amp; Scientific Integrity\u003c\/div\u003e\n    \u003ctable style=\"width:100%;border-collapse:collapse;margin-top:12px;font-size:13px;color:#A8B0BC;\"\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:6px 12px 6px 0;vertical-align:top;width:25%;\"\u003e\n\u003cspan style=\"color:#E8722A;\"\u003e◆\u003c\/span\u003e \u003cspan style=\"color:#FFFFFF;font-weight:bold;\"\u003ePurity\u003c\/span\u003e\u003cbr\u003eHPLC-verified ≥ 98% with batch CoA\u003c\/td\u003e\n        \u003ctd style=\"padding:6px 12px;vertical-align:top;width:25%;\"\u003e\n\u003cspan style=\"color:#E8722A;\"\u003e◆\u003c\/span\u003e \u003cspan style=\"color:#FFFFFF;font-weight:bold;\"\u003eEvidence\u003c\/span\u003e\u003cbr\u003ePeer-reviewed citations for all mechanistic claims\u003c\/td\u003e\n        \u003ctd style=\"padding:6px 12px;vertical-align:top;width:25%;\"\u003e\n\u003cspan style=\"color:#E8722A;\"\u003e◆\u003c\/span\u003e \u003cspan style=\"color:#FFFFFF;font-weight:bold;\"\u003eTransparency\u003c\/span\u003e\u003cbr\u003eEvidence limitations stated per molecule\u003c\/td\u003e\n        \u003ctd style=\"padding:6px 0 6px 12px;vertical-align:top;width:25%;\"\u003e\n\u003cspan style=\"color:#E8722A;\"\u003e◆\u003c\/span\u003e \u003cspan style=\"color:#FFFFFF;font-weight:bold;\"\u003eSafety\u003c\/span\u003e\u003cbr\u003eResearch use only — not for human or animal consumption\u003c\/td\u003e\n      \u003c\/tr\u003e\n    \u003c\/table\u003e\n  \u003c\/div\u003e\n\n  \u003c!-- 9 · RUO DISCLAIMER --\u003e\n  \u003cdiv style=\"background:#0D1B3E;color:#A8B0BC;padding:16px 18px;font-size:12.5px;line-height:1.6;\"\u003e\n    \u003cspan style=\"color:#E8722A;font-weight:bold;\"\u003eFor Research Use Only.\u003c\/span\u003e This product is strictly intended for laboratory and research use only. Not suitable for human or animal consumption, diagnostic, or therapeutic use. All use must comply with local regulations and ethical research standards.\u003cbr\u003e\n    \u003cspan style=\"color:#FFFFFF;\"\u003eTFLL Pharma · TFLL BV · Belgium\u003c\/span\u003e · Life Span · Health Span · Brain Span · www.tfllpharma.com\n  \u003c\/div\u003e\n\n\u003c\/div\u003e","brand":"customsupplements","offers":[{"title":"Default Title","offer_id":59324753543516,"sku":null,"price":195.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0617\/0014\/5391\/files\/selank_spray.jpg?v=1793712045","url":"https:\/\/customsupplementsshop.com\/products\/selank-10-mg-spray","provider":"customsupplements","version":"1.0","type":"link"}