Selank (10 mg) 195€ + Shipping ^Uitverkoop

Selank is a synthetic analog of tuftsin — the immunoactive IgG heavy-chain fragment — with a C-terminal Pro-Gly-Pro (PGP) tail added for peptidase resistance. It shares the glyproline stabilizing strategy of its sister molecule Semax. Selank is studied as a multi-target regulatory peptide across enkephalinergic, GABAergic and neuroimmune axes. This product is supplied as a research-grade aqueous nasal-spray solution for in vitro, ex vivo and analytical research only.

Investigational directions enabled by the published mechanism — not therapeutic claims.

• ◆Anxiety & stress neurobiology: behavioral anxiety models (EPM, chronic mild stress) and benzodiazepine-interaction studies
• ◆Opioid-peptide homeostasis: enkephalin degradation kinetics and peptidase inhibition
• ◆Neurotrophic signaling: hippocampal BDNF regulation after intranasal delivery (plasticity, memory)
• ◆Neuroimmune crosstalk: cytokine modulation (IL-6, Th1/Th2) inherited from the tuftsin scaffold

In published models, Selank inhibits enkephalinase (IC50 ≈ 15 µM), prolonging Leu-enkephalin half-life, and shows a transcriptional profile overlapping GABAergic signaling. Intranasal dosing raises hippocampal BDNF expression in rats, and the tuftsin-derived immune arm modulates IL-6 and Th1/Th2 cytokine balance.

Key literature: Zozulya et al., 2001 · Inozemtseva et al., 2008 · Uchakina et al., 2008 · Kasian et al., 2017.

Evidence note: the mechanism is multi-target — no single receptor has been defined; GABAergic effects are transcriptional and not seen in all cell models (e.g. IMR-32, 2017).